A .243 shooting a 58 gr V max is a coyote grenade. I too have killed several with that combo. It is moving at some serious velocity and will leave an exit wound you can put your fist through. Not great for saving pelts to make things out of, but dang it's fun to smoke them with that combo. It is down right hilarious on prairie dogs,...generally vaporizes them when you shoot them right square center mass.
Dirty Steve
I hit a coyote with a .243 Superformance Varmint and it didn't exit. Needless to say, it dumped all that energy into the yote and that thing dropped in its tracks.
It was a quartering front shoulder shot, I hit it right above the clavical and it literally turned its vital to giblets that fell out when I hung him up to skin him.
If I had hit all "soft" stuff, I'm sure there'd be a softball size hole exit
IF you're looking at a 243 as a do all round, also consider the 7mm-08, or the 260 Rem.
Bullet selection makes all of them great at filling multiple roles