6 days a week either a Sig P320c or P220 compact plus 1 mag and a Spyderco PM2.
Sunday is usually a S&W 442 in an ankle holster and a Kershaw Leek. Occasionally the Shield if I am wearing a sports coat.
Sometimes if I am just running up to the corner gas station at oh dark thirty in the morning I don't carry much. I will slip the little P64 in 9x18 Makarov in my pocket.
I have only one sidearm suitable for carry, S&W 1006, so no need or possibility to vary EDC.
The key is an excellent (Kramer horsehide) holster and a sturdy belt.
The only other sidearm option (the Ruger LCR is my wife's) is a 7-1/2" barrel Ruger Blackhawk .45 Colt, not exactly the most comfortable to carry concealed, even for me at 6'4", although still concealable in winter riding in a vertical shoulder holster.
Glock-27 plus a spare 15 rd standard mag, 180 gr Winchester PDX-1 is my MINIMUM around Fishers.
A Glock-22 with spare mag, cell phone if going back into the city, I consider MAXIMUM.
ZT 0450. Great Eastern Cutlery single blade folder. 1 KY coffee bean. CZ RAMI 9MM. Spare 10 round mag. Wallet. Cell phone. Keys. Space pen. Small tablet of paper. Ziploc with baby wipes.
If my Maxpedition murse is on board,
Leatherman Wave,
3 other good qualty folders,
Some minor first aid stuff,
100' of paracord
2 copies of my local G/S's ffl,
3 different size flashlights, s,m,l,
Microfiber cloth and cleaning solution for glasses,
And possibly a CZ75 and spare mag,
And a replica 45-110 cartridge cast of brass with Tom Selleck's signature cast into it and about a 14" lanyard for head knocking and DNA collection.