I started hunting when I was pretty young and when I started carrying a handgun I couldn't imagine not carrying with a round chambered. I couldn't get deer to stand around and wait till I was ready so I figured most bad guys wouldn't either. In all seriousness I have a real good friend who carries unchambered and this year we were going turkey hunting and I had to give him a rough time for loading his shotgun. He's been carrying for well over twenty years and still thinks he can rack the slide in time. To me it doesn't matter what kind of gun, the right holster makes it safe to carry any modern firearm chambered.