1: M&P 9mm. Used primarily as my EDC, but does everything. I shoot it in IDPA, and it serves in HD as well with an Inforce APL attached.
2: Springfield TRP. Used primarily as my fun gun. Shoots reeeeaaallly well, I can personalize it and make it my own which is important to me since I like to change things. Also a drool gun/bbq gun/halo gun. Can be used as EDC or competition if need be. Finally, I have a .22 slide for it so I can have "cheap" fun. Or at least I used to be able to have cheap fun...
3: CZ SP-01 or Shadow (currently agonizing in wait for a Shadow). This would be used primarily as a competition gun, but could serve well in HD or EDC.
I like my guns to be able to serve well as EDC/Comp/HD so I can cycle them out as I get bored or want to train with something new. Keeps it fresh.
My ideal 3 right now would be:
glock 19 for edc/nightstand duty/whatever else
Springfield trp, because they are cool
3rd would probably be a sig 229, simply for nostalgic reasons
1) LC9s (9mm) EDC exchanged with #2 depending on clothing.
2) CZ-P01 (9mm) EDC Probably the best carry gun on the market (IMHO)
3) CZ97b - (45 auto) for the home... I would also recommend a good 12g shotty.. which ever brand of pump action you want. (12g best home protection)
If I could only have 3 hand guns, I think this is my list. It was hard to not put the 1911 in, but the 97b is a great shooter with a double stack 10 round mag.